The Minnesota Vikings, the NFL's last unbeaten team, will put their perfect record on the line Sunday when they visit the Detroit Lions, who are favored by 3.5 points. Other Week 8 matchups featuring one-loss teams include the 5-1 Kansas City Chiefs against the Denver Broncos (+1.5) and the Baltimore Ravens facing the 5-1 Buffalo Bills (-3), with Ravens quarterback Lamar Jackson set to return from an ankle injury that sidelined him for three games.
Additional divisional games include the Atlanta Falcons at the Tampa Bay Buccaneers (-2.5), Cleveland Browns at the Pittsburgh Steelers (-3.5), Indianapolis Colts at the Jacksonville Jaguars (-10), New England Patriots at the Miami Dolphins (+7), and the Philadelphia Eagles at the Washington Commanders (-5.5) on Sunday Night Football. The Patriots and Chiefs are the only road favorites this week.
SportsLine's computer model, which simulates each NFL game 10,000 times, has produced five best bets for Week 8. The model has generated more than $5,000 in profit for $100 players on top-rated picks since its inception and entered Week 8 on a 58-51 run on top-rated selections dating back to 2024. A successful parlay of the model's five picks would pay nearly 25-1.
The model's top pick is the Over 46.5 points in the Colts-Jaguars game, which hits in 66% of simulations. The Over has cashed in six of the last 10 head-to-head meetings, is 6-4 in Indianapolis' last 10 games, and hit in Jacksonville's most recent contest. Jacksonville ranks seventh in scoring at 25.7 points per game, tied with Chicago, while Indianapolis allows 25.7 points per game and recently traded defensive lineman DeForest Buckner.
Indianapolis is led by running back Jonathan Taylor, who has rushed 140 times for 587 yards (4.2 average) and eight touchdowns in seven games. Quarterback Daniel Jones has completed 59.6% of his passes for 1,398 yards, four touchdowns, and seven interceptions. For Jacksonville, Trevor Lawrence has completed 65.2% of his passes for 1,480 yards, 14 touchdowns, four interceptions, and a 106.3 passer rating in six starts. Wide receiver Parker Washington has 26 catches for 416 yards (16.0 average) and four touchdowns.
The model also identified four other matchups where it believes the line is significantly off, including multiple spread picks that hit well over 50% of the time in simulations. The full set of Week 8 best bets and the parlay are available through SportsLine.
