College football Week 10 features a loaded slate of marquee matchups, with oddsmakers releasing opening lines for the biggest games. The highlight is No. 1 Miami visiting No. 5 Notre Dame, where the Fighting Irish opened as 4.5-point favorites despite Miami's top ranking.
Key Matchups
No. 15 LSU hosts No. 10 Alabama as a 3.5-point favorite in a potential College Football Playoff elimination game. The Tigers have lost six of their last seven home games against the Crimson Tide.
No. 8 BYU travels to No. 6 Utah for the Holy War, with Utah favored by 4.5 points. Both teams are eyeing a Big 12 championship and a playoff berth.
No. 11 Texas is a 3.5-point favorite at No. 23 Missouri, while No. 2 Ohio State is a 10.5-point favorite over Oregon despite a recent loss to USC.
No. 3 Georgia is a 3.5-point favorite at No. 12 Ole Miss in another game with playoff implications. Other notable lines include No. 16 Tennessee (-6.5) vs. No. 9 Kentucky, No. 19 SMU (-6.5) vs. Virginia Tech, and Michigan (-13.5) vs. Michigan State.
