Syracuse Orange have opened as slight underdogs for their upcoming matchup against the Clemson Tigers, according to early betting lines released Sunday. The Orange are coming off a dramatic victory on October 31, 2026, when tight end Noah Meyers caught the winning touchdown in the second half to defeat the SMU Mustangs at the JMA Wireless Dome.
The narrow underdog status reflects the challenge Syracuse faces against a perennial powerhouse in Clemson. The game will test whether the Orange can build on their recent momentum against one of college football's elite programs.
