San Francisco 49ers defensive end Nick Bosa and running back Christian McCaffrey are set to play against the Las Vegas Raiders, while wide receivers Mike Evans and Deebo Samuel have been ruled out, according to a report from ClutchPoints on November 6, 2026.
The 49ers will have their star pass rusher and offensive centerpiece available for the matchup, but will be without two key receiving options. Evans and Samuel's absences could significantly impact San Francisco's passing attack.
