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Week 10 College Football Picks: Expert Analysis Highlights Key Playoff Matchups

Week 10 College Football Picks: Expert Analysis Highlights Key Playoff Matchups
World Sports · 02:29:22 - Tuesday, 10 November 2026

Week 10 of the college football season features a loaded schedule with several matchups that will directly impact the College Football Playoff rankings following the initial release earlier this week.

Key Matchups and Odds

Top-ranked Miami travels to No. 11 Notre Dame, with the Irish listed as 7-point favorites. Miami star receiver Malachi Toney is out due to an ankle injury. Two games feature top-10 teams in the CFP rankings facing each other: No. 10 Ole Miss at No. 2 Georgia (Georgia favored by 3.5 points) and No. 3 Utah at No. 9 BYU (Utah favored by 4.5 points). Other games with playoff implications include No. 5 Alabama at No. 14 LSU (LSU -6), No. 6 Kentucky at No. 13 Tennessee (Tennessee -6), No. 7 Texas at No. 18 Missouri (Texas -2.5), and No. 23 Oregon at No. 12 Ohio State (Ohio State -7.5).

Expert Analysis from Thomas Casale

Veteran sports betting expert Thomas Casale, a frequent guest on national radio and TV shows with over 30 years of experience, has posted a 14-8 record over the last seven weeks and swept his best bets in Weeks 4 and 5. For Week 10, Casale is backing Ohio State (-7.5) to cover against Oregon in a 3:30 p.m. ET Big Ten matchup on Saturday. Ohio State fell at USC last week and faces pressure to avoid a third loss that would jeopardize playoff hopes. Oregon, at 5-3, is below expectations despite a win over ranked Northwestern.

Casale noted that Ohio State's true freshman quarterback Luke Fahey struggled in his first career start at USC, completing 21 of 38 passes for 260 yards and a touchdown. He expects Ohio State's defense to improve after allowing 30 points to USC. Oregon backup quarterback Dylan Raiola had his best game last week but has shown vulnerability under pressure. Casale also anticipates increased involvement for receiver Jeremiah Smith now that Fahey has a start under his belt.

Casale has identified two additional best bets for Week 10, including a favorite expected to roll against a team that might be demoralized. Details on those picks are available through his subscription service.

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