The Minnesota Vikings remain the NFL's only unbeaten team heading into Week 8 and will put their perfect record on the line against the Detroit Lions, who are favored by 3.5 points, on Sunday. Other notable games featuring one-loss teams include the 5-1 Kansas City Chiefs visiting the Denver Broncos as 1.5-point underdogs, and the Baltimore Ravens hosting the 5-1 Buffalo Bills with the Bills favored by three points as quarterback Lamar Jackson trends toward returning from an ankle injury.
Divisional matchups highlight Week 8 schedule
The Week 8 slate features several divisional contests: the Atlanta Falcons visit the Tampa Bay Buccaneers (-2.5), the Cleveland Browns travel to the Pittsburgh Steelers (-3.5), the Indianapolis Colts face the Jacksonville Jaguars (-10), the New England Patriots visit the Miami Dolphins (+7), and the Philadelphia Eagles host the Washington Commanders (-5.5) on Sunday Night Football. The Patriots and Chiefs are the only road favorites this week.
Computer model identifies five best bets
SportsLine's computer model, which simulates each NFL game 10,000 times, entered Week 8 of the 2026 season on a 58-51 run on top-rated picks dating back to 2024 and has returned more than $5,000 for $100 players since its inception. The model has locked in five confident best bets for Week 8; a successful parlay of those picks would pay nearly 25-1.
Over 46.5 backed in Colts-Jaguars
The model's top pick is the Over 46.5 points in the Colts-Jaguars game, which hits in 66% of simulations. The Over has cashed in six of the last 10 head-to-head meetings, is 6-4 in the last 10 Indianapolis games, and hit in Jacksonville's most recent contest. Jacksonville ranks seventh in the NFL in scoring, tied with the Chicago Bears at 25.7 points per game, while Indianapolis allows 25.7 points per game and recently traded defensive lineman DeForest Buckner.
Indianapolis is led by running back Jonathan Taylor, who has carried 140 times for 587 yards (4.2 average) and eight touchdowns in seven games. Quarterback Daniel Jones has completed 59.6% of his passes for 1,398 yards and four touchdowns with seven interceptions. For Jacksonville, quarterback Trevor Lawrence has completed 65.2% of his passes for 1,480 yards and 14 touchdowns with four interceptions and a 106.3 passer rating in six starts. Wide receiver Parker Washington has 26 receptions for 416 yards (16.0 average) and four touchdowns.
Additional spread picks identified
The model also identified four other matchups where it believes the line is significantly off, including multiple spread picks that hit well over 50% of the time in simulations.
