Week 10 college football odds feature numerous one-score lines, with seven matchups involving teams from the initial College Football Playoff rankings. In the SEC, Alabama visits LSU as a 6-point underdog, Georgia travels to Ole Miss at +3.5, and Texas faces Missouri at +2.5. Elsewhere, No. 1 Miami visits No. 11 Notre Dame with the Fighting Irish favored by 7 points, while Miami will be without injured wide receiver Malachi Toney. In a historic rivalry, BYU seeks a fourth straight win over Utah, with the Utes favored by 4.5 points at home.
Model Predictions and Top Picks
SportsLine's simulation model, which entered Week 10 with an 80-77 record on top-rated picks, projects Ohio State (-7.5) to cover against Oregon in a 3:30 p.m. ET kickoff. The Buckeyes have covered 80% of home games since the start of 2025 and are projected to win by double digits. Another highlighted pick is Oklahoma (+5.5) covering at Florida, with the model giving the Sooners over a 50% cover probability. Florida has lost three of four games by 19-plus points and leads the SEC in penalty yards, while Oklahoma quarterback John Mateer has averaged 296.5 total yards with four passing touchdowns and zero turnovers over his last two games. The model also projects the Over in the Oklahoma-Florida game to hit in 59% of simulations.
Notable Week 10 Odds
Key games and spreads for Saturday, Nov. 7 include: BYU at Utah (-4.5, 49.5), Texas at Missouri (+2.5, 42.5), UCLA at Minnesota (+3.5, 38.5), Alabama at LSU (-6, 52.5), Oregon at Ohio State (-7.5, 45.5), Kentucky at Tennessee (-6, 49.5), Air Force at Army (-4, 43.5), Miami at Notre Dame (-7, 54.5), Michigan State at Michigan (-14, 39.5), Georgia at Ole Miss (+3.5, 56.5), and Oklahoma at Florida (-5.5, 45.5). The model projects three upsets in ranked matchups, with full picks available via SportsLine.
