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World Sports

College Football Week 10 Predictions and Odds: Top-10 Matchups Highlight Schedule

College Football Week 10 Predictions and Odds: Top-10 Matchups Highlight Schedule
World Sports · 02:21:00 - Tuesday, 10 November 2026

Week 10 of the college football season features six ranked teams, highlighted by a pair of top-10 matchups. No. 9 BYU travels to No. 3 Utah with the Utes favored by 4.5 points, while top-ranked Miami visits No. 11 Notre Dame as a 7-point underdog. The Hurricanes will be without leading receiver Malachi Toney due to an ankle injury.

Other notable lines include No. 2 Georgia at No. 10 Ole Miss (+3.5), No. 5 Alabama at No. 14 LSU (-6.5), No. 7 Texas at No. 18 Missouri (+2.5), and No. 12 Ohio State hosting Oregon as a 7.5-point favorite. The SportsLine projection model, which simulates every FBS game 10,000 times, enters the week on an 80-77 run on top-rated picks.

The model projects No. 13 Tennessee (-6) to defeat No. 6 Kentucky 27-19 in a 6:15 p.m. ET kickoff on Saturday. Tennessee covers the spread in 53% of simulations, while the under on the 49.5-point total hits 62% of the time. Kentucky, under first-year coach Will Stein, has surged to a 7-1 record (5-1 SEC) but faces its toughest road test at Neyland Stadium, where Tennessee has covered in every SEC home game this season and beat Alabama by 16 points in its last home outing.

Notable Week 10 Lines

Friday, Nov. 6: Virginia Tech at SMU (-6.5, 56.5); USF at East Carolina (-2.5, 39.5); Nebraska at Illinois (+4.5, 50.5); New Mexico at Nevada (+9.5, 38.5); TCU at Arizona (-7, 46.5).

Saturday, Nov. 7: BYU at Utah (-4.5, 48.5); Texas at Missouri (+2.5, 42.5); UCLA at Minnesota (+5, 38.5); Alabama at LSU (-6.5, 52.5); Cincinnati at Houston (-10.5, 62.5); Oregon at Ohio State (-7.5, 45.5); Kentucky at Tennessee (-6.5, 49.5); Air Force at Army (-3, 44.5); Miami at Notre Dame (-7.5, 54.5); Michigan State at Michigan (-14.5, 39.5); Georgia at Ole Miss (+3.5, 56.5); Oklahoma at Florida (-6.5, 44.5).

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